Article
Detection of breakpoint cluster region- negative and nonclonal hematopoiesis in vitro and in vivo after transplantation of cells selected in cultures of chronic myeloid leukemia marrow.
Blood - 1 Dec 1990
Turhan A G, Humphries R K, Eaves C J, Barnett M J, Phillips G L, Kalousek D K, Klingemann H G, Lansdorp P L, Reece D E, Shepherd J D
Abstract excerpt
Philadelphia (Ph1) chromosome-positive clonogenic progenitors usually disappear within 4 to 6 weeks in long-term cultures established from the marrow of patients with chronic myeloid leukemia (CML). In contrast, coexisting chromosomally normal hematopoietic cells are relatively well maintained. T...
Topics
- Bone Marrow
- Bone Marrow Transplantation
- Cell Adhesion
- Chromosomes, Human, Pair 22
- Clone Cells
- DNA Restriction Enzymes
- Gene Rearrangement
- Genotype
- Granulocytes
- Hematopoiesis
- Hematopoietic Stem Cells
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive