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Article

Disparity of innate immunity-related gene effects on asthma and allergy on Karelia.

Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology - 1 Sept 2011

Zhang Guicheng, Candelaria Pierre, Mäkelä J Mika, Khoo Siew-Kim, Hayden M Catherine, von Hertzen Leena, Laatikainen Tiina, Vartiainen Erkki, Goldblatt Jack, Haahtela Tari, LeSouëf N Peter

Abstract excerpt

BACKGROUND: We investigated the interactive effects of 11 innate immunity-related genes (IL10, IL12b, IL8, TLR2, TLR4, CD14, IFNGR, CC16, IFNg, CMA1, and TGFB) and four IgE response genes (IL4, IL13, IL4RA, and STAT6) with 'Western' or 'Eastern' environments/lifestyles on asthma and allergy in Karelian children. METHODS: Karelian children (412 Finnish and 446 Russian) were recruited and assessed for a range of...

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Identifiers

PMID: 21749458
DOI: 10.1111/j.1399-3038.2011.01186.x

Genes

STAT6
CMA1
TLR2
TLR4

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