Article
Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from Europe.
Molecular psychiatry - 1 Sept 2012
Rietschel M, Mattheisen M, Degenhardt F, Mühleisen T W, Kirsch P, Esslinger C, Herms S, Demontis D, Steffens M, Strohmaier J, Haenisch B, Breuer R, Czerski P M, Giegling I, Strengman E, Schmael C, Mors O, Mortensen P B, Hougaard D M, Ørntoft T, Kapelski P, Priebe L, Basmanav F F, Forstner A J, Hoffman P, Meier S, Nikitopoulos J, Moebus S, Alexander M, Mössner R, Wichmann H -E, Schreiber S, Rivandeneira F, Hofman A, Uitterlinden A G, Wienker T F, Schumacher J, Hauser J, Maier W, Cantor R M, Erk S, Schulze T G, Craddock N, Owen M J, O'Donovan M C, Børglum A D, Rujescu D, Walter H, Meyer-Lindenberg A, Nöthen N M, Ophoff R A, Cichon S
Abstract excerpt
Recent molecular studies have implicated common alleles of small to moderate effect and rare alleles with larger effect sizes in the genetic architecture of schizophrenia (SCZ). It is expected that the reliable detection of risk variants with very small effect sizes can only be achieved through the recruitment of very large samples of patients and controls (that is tens of thousands), or large, potentially more...
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