Article
[Selection of a herpes simplex mutant virus of weak pathogenicity, sensitive to acyclovir and not susceptible to reactivation in vivo].
Ophtalmologie : organe de la Societe francaise d'ophtalmologie - 1 Jan 2000
Colin J, Jouppe B, Robinet A, Huraux J M, Chastel C
Abstract excerpt
From a KOS herpes simplex virus strain prepared in VERO cells we have been able to obtain after several exposures to increasing concentrations of trifluorothymidine, four resistant mutants. Among these strains, 31 T mutant was a TK-altered strain of low pathogenicity, sensible to acyclovir and did not induce recurrences. These properties might allow the use of such a strain as a living attenuated antiherpetic...
Topics
- Acyclovir
- Microbial Sensitivity Tests
- Mutation
- Simplexvirus