Article
Exon 2 deletion splice variant of gamma-glutamyl carboxylase causes des-gamma-carboxy prothrombin production in hepatocellular carcinoma cell lines.
Molecular oncology - 1 Oct 2008
Ueda Naoki, Shiraha Hidenori, Fujikawa Tatsuya, Takaoka Nobuyuki, Nakanishi Yutaka, Suzuki Mayumi, Matsuo Noriyuki, Tanaka Shigetomi, Nishina Shin-Ichi, Uemura Masayuki, Takaki Akinobu, Shiratori Yasushi, Yamamoto Kazuhide
Abstract excerpt
Using GGCX gene-specific real-time PCR, exon 2 deletion splice variant of vitamin K-dependent gamma-glutamyl carboxylase (GGCX) mRNA was identified in HCC cell lines. Expressions of wild type and exon 2 deletion variant of GGCX were analyzed with relevance to DCP production in HCC cell lines. Hep3B, HepG2, HuH1, HuH7, and PLC/PRF/5 produced DCP, while SK-Hep-1, HLE, HLF, and JHH1 produced no detectable level of...
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