Article
Identification of amino acids in highly pathogenic avian influenza H5N1 virus hemagglutinin that determine avian influenza species specificity.
Archives of virology - 1 Oct 2011
Li Zheng, Liu Zhonghua, Ma Chi, Zhang Linqi, Su Yuelong, Gao George F, Li Zi, Cui Lianxian, He Wei
Abstract excerpt
To test the role of neutralizing antibodies (nAbs) and receptor adaptation in interspecies transmission of influenza virus, two H5N1 strains, isolated from human and avian hosts, with four amino acid differences in hemagglutinin (HA) and seven HA mutations were studied. We found that a mutation at amino acid position 90 in the H5N1 HA, outside the receptor-binding domain (RBD), could simultaneously induce changes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.