Article
Warfarin-associated hemorrhage and cerebral amyloid angiopathy: a genetic and pathologic study.
Neurology - 10 Oct 2000
Rosand J, Hylek E M, O'Donnell H C, Greenberg S M
Abstract excerpt
BACKGROUND: Intracerebral hemorrhage (ICH) is the most feared complication of warfarin therapy. The pathogenesis of this often-fatal complication remains obscure. Cerebral amyloid angiopathy (CAA) is a major cause of spontaneous lobar hemorrhage in the elderly and is associated with specific alleles of the APOE gene. OBJECTIVE: To assess the role of CAA in warfarin-associated ICH. METHODS: Clinical...
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