APOE ε variants increase risk of warfarin-related intracerebral hemorrhage.

doi:10.1212/WNL.0000000000000816

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Article

APOE ε variants increase risk of warfarin-related intracerebral hemorrhage.

Neurology - 23 Sept 2014

Falcone Guido J, Radmanesh Farid, Brouwers H Bart, Battey Thomas W K, Devan William J, Valant Valerie, Raffeld Miriam R, Chitsike Lennox P, Ayres Alison M, Schwab Kristin, Goldstein Joshua N, Viswanathan Anand, Greenberg Steven M, Selim Magdy, Meschia James F, Brown Devin L, Worrall Bradford B, Silliman Scott L, Tirschwell David L, Flaherty Matthew L, Martini Sharyl R, Deka Ranjan, Biffi Alessandro, Kraft Peter, Woo Daniel, Rosand Jonathan, Anderson Christopher D

Abstract excerpt

OBJECTIVE: We aimed to assess the effect of APOE ε variants on warfarin-related intracerebral hemorrhage (wICH), evaluated their predictive power, and tested for interaction with warfarin in causing wICH. METHODS: This was a prospective, 2-stage (discovery and replication), case-control study. wICH was classified as lobar or nonlobar based on the location of the hematoma. Controls were sampled from ambulatory...

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PMID: 25150286
DOI: 10.1212/WNL.0000000000000816
PMCID: PMC4176027

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APOE

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