Article
TP53 Arg72Pro polymorphism in Turkish patients with sporadic amyotrophic lateral sclerosis.
Neurobiology of aging - 1 Nov 2011
Ergul Emel, Ozel Mavi Deniz, Sazci Ali, Idrisoglu Halil Atilla
Abstract excerpt
Recently, Eve et al. (2007) reported that the expression of TP53 (NM_000546) was increased by 2.1-fold in whole spinal cord and 2.7-fold in the ventral horn of amyotrophic lateral sclerosis (ALS) patients. Based on this particular observation, we decided to evaluate whether the TP53 Arg72Pro polymorphism (rs1042522) (C215G) was implicated in the etiopathology of sporadic amyotrophic lateral sclerosis (SALS)....
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