Article
Association between metallothionein genes polymorphisms and sporadic amyotrophic lateral sclerosis in a Japanese population.
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases - 1 Mar 2006
Hayashi Yuichi, Hashizume Tatsuma, Wakida Kenji, Satoh Masahiko, Uchida Yoko, Watabe Kazuhiko, Matsuyama Zenjiro, Kimura Akio, Inuzuka Takashi, Hozumi Isao
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a progressive, lethal neurodegenerative disease that selectively affects motor neurons. Reactive oxygen species (ROS) are assumed to be involved in the pathogenesis of ALS. Metallothioneins (MTs) are self-protective, multifunctional proteins that scavenge ROS. In particular, metallothionein-III (MT-III) has a strong scavenging effect on hydroxyl radicals. MTs have been...
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