Article
Molecular determinants of disease in coxsackievirus B1 murine infection.
Journal of medical virology - 1 Sept 2011
Cifuente Javier O, Ferrer María F, Jaquenod de Giusti Carolina, Song Wen-Chao, Romanowski Víctor, Hafenstein Susan L, Gómez Ricardo M
Abstract excerpt
To understand better how different genomic regions may confer pathogenicity for the coxsackievirus B (CVB), two intratypic CVB1 variants, and a number of recombinant viruses were studied. Sequencing analysis showed 23 nucleotide changes between the parental non-pathogenic CVB1N and the pathogenic CVB1Nm. Mutations present in CVB1Nm were more conserved than those in CVB1N when compared to other CVB sequences....
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