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Article

A point mutation in the VP4 coding sequence of coxsackievirus B4 influences virulence.

Journal of virology - 1 Nov 1995

Ramsingh A I, Collins D N

Abstract excerpt

In analyzing the molecular determinants of virulence of coxsackievirus B4, chimeric viruses were constructed from avirulent and virulent viruses. The vCB424 recombinant contained a single nucleotide substitution on an avirulent genetic background, resulting in replacement of Ser-16 of VP4 with Arg-16. Mice infected with vCB424 displayed an intermediate phenotype.

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Source

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Identifiers

PMID: 7474153
DOI: 10.1128/JVI.69.11.7278-7281.1995
PMCID: PMC189653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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