Article
A point mutation in the VP4 coding sequence of coxsackievirus B4 influences virulence.
Journal of virology - 1 Nov 1995
Ramsingh A I, Collins D N
Abstract excerpt
In analyzing the molecular determinants of virulence of coxsackievirus B4, chimeric viruses were constructed from avirulent and virulent viruses. The vCB424 recombinant contained a single nucleotide substitution on an avirulent genetic background, resulting in replacement of Ser-16 of VP4 with Ar...
Topics
- Amino Acid Sequence
- Amylases
- Animals
- Arginine
- Capsid
- Capsid Proteins
- Chimera
- Coxsackievirus Infections
- Enterovirus B, Human
- Genotype
- Mice
- Pancreas
- Phenotype
- Point Mutation
- Restriction Mapping
- Serine
- Viral Plaque Assay
- Virulence