Article
Severe chemotherapy-related hepatic toxicity associated with MZ protease inhibitor phenotype.
The American journal of pediatric hematology/oncology - 1 Jan 1990
Ruchelli E D, Horn M, Taylor S R
Abstract excerpt
We describe a 10 1/2-month-old boy in whom fulminant hepatic failure following chemotherapy for Wilms' tumor developed. He then received an orthotopic liver transplant. An unexpected finding was the accumulation of alpha 1-antitrypsin (AAT) in periportal hepatocytes. A pretransplant serum sample...
Topics
- Alleles
- Antineoplastic Combined Chemotherapy Protocols
- Chemical and Drug Induced Liver Injury
- Dactinomycin
- Disease Susceptibility
- Hemorrhage
- Heterozygote
- Humans
- Infant
- Kidney Neoplasms
- Liver Diseases
- Liver Transplantation
- Male
- Necrosis
- Phenotype
- Vincristine
- Wilms Tumor
- alpha 1-Antitrypsin