Article
Association of GSTM1 and GSTT1 polymorphisms with chronic obstructive pulmonary disease in a Tunisian population.
Biochemical genetics - 1 Aug 2010
Lakhdar Ramzi, Denden Sabri, Knani Jalel, Leban Nadia, Daimi Houria, Hassine Mohsen, Lefranc Gérard, Ben Chibani Jemni, Haj Khelil Amel
Abstract excerpt
GSTM1 and GSTT1 polymorphisms have been proposed in relationship with chronic obstructive pulmonary disease (COPD). We investigated the association between these polymorphisms and COPD (as well as its subtypes emphysema and chronic bronchitis) in 234 COPD patients and 182 healthy controls in the Tunisian population. Genotyping was performed using multiplex PCR. GSTM1-null genotype frequency was significantly...
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