Article
The FOXE1 and NKX2-1 loci are associated with susceptibility to papillary thyroid carcinoma in the Japanese population.
Journal of medical genetics - 1 Sept 2011
Matsuse Michiko, Takahashi Meiko, Mitsutake Norisato, Nishihara Eijun, Hirokawa Mitsuyoshi, Kawaguchi Takahisa, Rogounovitch Tatiana, Saenko Vladimir, Bychkov Andrey, Suzuki Keiji, Matsuo Keitaro, Tajima Kazuo, Miyauchi Akira, Yamada Ryo, Matsuda Fumihiko, Yamashita Shunichi
Abstract excerpt
BACKGROUND: FOXE1 and NKX2-1 are two known genetic risk factors for the predisposition to sporadic papillary thyroid carcinoma (PTC) in Europeans, but their association in other ethnicities is still unknown. OBJECTIVE: We aim to examine the association of the two genes with Japanese sporadic PTC, which exhibits high BRAF(V600E) mutation rate. METHODS: 507 Japanese sporadic PTC cases and 2766 controls were...
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