Article
A single amino acid substitution in the large subunit of herpes simplex virus type 1 ribonucleotide reductase which prevents subunit association.
The Journal of general virology - 1 Oct 1990
Nikas I, Darling A J, Lankinen H M, Cross A M, Marsden H S, Clements J B
Abstract excerpt
The herpes simplex virus type 1 temperature-sensitive (ts) mutant ts1207 does not induce detectable levels of ribonucleotide reductase activity at the non-permissive temperature (NPT, 39.5 degrees C). The ts lesion prevents the association of the enzyme's large (RR1) and small (RR2) subunits to g...
Topics
- Amino Acid Sequence
- Base Sequence
- Macromolecular Substances
- Molecular Sequence Data
- Molecular Structure
- Mutation
- Oligopeptides
- Protein Conformation
- Ribonucleotide Reductases
- Simplexvirus
- Structure-Activity Relationship
- Temperature