Article
A single amino acid substitution in the large subunit of herpes simplex virus type 1 ribonucleotide reductase which prevents subunit association.
The Journal of general virology - 1 Oct 1990
Nikas I, Darling A J, Lankinen H M, Cross A M, Marsden H S, Clements J B
Abstract excerpt
The herpes simplex virus type 1 temperature-sensitive (ts) mutant ts1207 does not induce detectable levels of ribonucleotide reductase activity at the non-permissive temperature (NPT, 39.5 degrees C). The ts lesion prevents the association of the enzyme's large (RR1) and small (RR2) subunits to give an active holoenzyme and maps within the gene specifying RR1. Here, it is shown that the ts mutant phenotype is due...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.