Article
Phenotypic similarities and differences between UL37-deleted pseudorabies virus and herpes simplex virus type 1.
The Journal of general virology - 1 Jul 2009
Leege Tobias, Granzow Harald, Fuchs Walter, Klupp Barbara G, Mettenleiter Thomas C
Abstract excerpt
In the absence of the tegument protein pUL37, virion formation of pseudorabies virus (PrV) and herpes simplex virus type 1 (HSV-1) is severely impaired. Non-enveloped nucleocapsids accumulate in clusters in the cytoplasm, whereas only a few enveloped particles can be detected. Although a contribution of pUL37 to nuclear egress of HSV-1 has been suggested, the nuclear stages of morphogenesis are not impaired in...
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