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PARP inhibitors in cancer therapy: an update

5 Feb 2013

Abstract excerpt

INTRODUCTION: Inhibitors of the poly(ADP-ribose) polymerases (PARPs) family of proteins are currently being evaluated as potential anticancer medicines at both preclinical and clinical levels. They have the peculiarity to increase the efficacy of DNA-damaging agents and to selectively target tumor cells with specific DNA repair defects. This later development of these drugs should make it possible, in principle,...

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PMID: 23379721
DOI: 10.1517/13543776.2013.768615

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