Article
The prognostic value of p53 mutation in pediatric marrow hypoplasia.
Diagnostic pathology - 30 Jun 2011
Abo-Elwafa Hasnaa A, Attia Fadia M, Sharaf Alzahraa E A
Abstract excerpt
BACKGROUND: The tumor suppressor gene p53 is involved in the control of cell proliferation, particularly in stressed cells. p 53 gene mutations are the most frequent genetic event found in human cancers. Fanconi Anemia (FA) is the most common representative of inherited bone marrow failure syndromes (IBMFS) with a leukemic propensity. P 53 DNA alteration has not been studied before in Egyptian children with FA....
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