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Article

NOD dendritic cells stimulated with Lactobacilli preferentially produce IL-10 versus IL-12 and decrease diabetes incidence.

Clinical & developmental immunology - 1 Jan 2011

Manirarora Jean N, Parnell Sarah A, Hu Yoon-Hyeon, Kosiewicz Michele M, Alard Pascale

Abstract excerpt

Dendritic cells (DCs) from NOD mice produced high levels of IL-12 that induce IFNγ-producing T cells involved in diabetes development. We propose to utilize the microorganism ability to induce tolerogenic DCs to abrogate the proinflammatory process and prevent diabetes development. NOD DCs were stimulated with Lactobacilli (nonpathogenic bacteria targeting TLR2) or lipoteichoic acid (LTA) from Staphylococcus...

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Identifiers

PMID: 21716731
DOI: 10.1155/2011/630187
PMCID: PMC3119457

Genes

LTA
TLR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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