Article
Host species and strain differences affect the ability of an HSV-1 ICP0 deletion mutant to establish latency and spontaneously reactivate in vivo.
Virology - 1 Oct 1990
Gordon Y J, McKnight J L, Ostrove J M, Romanowski E, Araullo-Cruz T
Abstract excerpt
HSV-1 latency and reactivation were studied in vivo by spontaneous and iontophoresis-induced ocular viral shedding in New Zealand rabbits, Balb/c and A/J mice latently infected with wild-type KOS, and dl x 3.1, a progeny ICP0 deletion mutant. The presence of trigeminal ganglionic latency was demo...
Topics
- Animals
- Cells, Cultured
- Eye Infections, Viral
- Herpes Simplex
- Host-Parasite Interactions
- Hydroxydopamines
- Immediate-Early Proteins
- Iontophoresis
- Mice
- Mice, Inbred BALB C
- Mutation
- Neurons
- Oxidopamine
- Rabbits
- Simplexvirus
- Ubiquitin-Protein Ligases
- Viral Proteins
- Virus Activation