Article
TERC polymorphisms are associated both with susceptibility to colorectal cancer and with longer telomeres.
Gut - 1 Feb 2012
Jones A M, Beggs A D, Carvajal-Carmona L, Farrington S, Tenesa A, Walker M, Howarth K, Ballereau S, Hodgson S V, Zauber A, Bertagnolli M, Midgley R, Campbell H, Kerr D, Dunlop M G, Tomlinson I P M
Abstract excerpt
BACKGROUND AND AIMS: Shorter telomeres have been associated with increased risk of malignancy, including colorectal cancer (CRC). Telomere length is heritable and may be an intermediate phenotype linked to genetic susceptibility to CRC. METHODS: In a large sample, the study investigated whether candidate single nucleotide polymorphisms (SNP) in 'telomere biology' genes were associated with telomere length in...
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