Article
Multidrug resistance gene expression and ABCB1 SNPs in plasma cell myeloma.
Leukemia research - 1 Nov 2011
Drain Stephen, Flannely Louise, Drake Mary B, Kettle Paul, Orr Nick, Bjourson Anthony J, Catherwood Mark A, Alexander H Denis
Abstract excerpt
Multi-drug resistance (MDR) leads to impaired treatment efficacy in all forms of malignancy. The main forms of MDR are thought to be mediated by the substrate transporting actions of certain adenosine triphosphate binding cassette (ABC) transport proteins. The genes ABCB1, ABCB4, ABCC1, ABCG2 and LRP1 have been identified as the most prominent contributors to clinically significant MDR. To date, no study has...
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