ABCB1 (MDR1) rs1045642 is associated with increased overall survival in plasma cell myeloma.

doi:10.1080/10428190902853144

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Article

ABCB1 (MDR1) rs1045642 is associated with increased overall survival in plasma cell myeloma.

Leukemia & lymphoma - 1 Apr 2009

Drain Stephen, Catherwood Mark A, Orr Nick, Galligan Leeona, Rea I Maeve, Hodkinson Clare, Drake Mary B, Kettle Paul J, Morris T C M Curly, Alexander H Denis

Abstract excerpt

Multi-drug resistance (MDR) may compromise the successful management of haematological malignancies, impairing the effectiveness of chemotherapy. The P-glycoprotein (P-gp) drug efflux pump, encoded by the gene ABCB1 (MDR1), is the most widely studied component in MDR. A single nucleotide polymorphism (SNP) has been identified within ABCB1, rs1045642 (C3435T), which may alter P-gp substrate specificity and have an...

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Identifiers

PMID: 19373654
DOI: 10.1080/10428190902853144

Genes

ABCB1

Variants

rs1045642

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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ABCB1 (MDR1) rs1045642 is associated with increased overall survival in plasma cell myeloma.PMID 19373654Read ↗

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