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Article

Severe combined immunodeficiency in man with an absence of immunoglobulin gene rearrangements but normal T cell receptor assembly.

European journal of immunology - 1 Sept 1990

Thompson A, Hendriks R W, Kraakman M E, Koning F, Langlois-van den Bergh R, Vossen J M, Weemaes C M, Schuurman R K

Abstract excerpt

An autosomal recessive type of severe combined immunodeficiency disease (SCID) was characterized by an absence of immunoglobulins (Ig) in the serum and of Ig+ lymphocytes in bone barrow (BM) and peripheral blood. In the BM CD10+/terminal deoxynucleotidyl transferase-positive lymphocytes were identified. Epstein-Barr virus-transformed B lymphoblastoid cell lines (BLCL) obtained from BM and peripheral blood did not...

Topics

Antigens, CD
B-Lymphocytes
Cell Line
Cell Transformation, Viral
Gene Rearrangement
Genes, Immunoglobulin
Herpesvirus 4, Human
Humans
Immunoglobulins
Immunologic Deficiency Syndromes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Receptors, Antigen, T-Cell

Source

Identifiers

PMID: 2170148
DOI: 10.1002/eji.1830200925

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2170148-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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