Article
Buffer enhancement of proton transfer in catalysis by human carbonic anhydrase III.
Biochemistry - 10 Jul 1990
Tu C K, Paranawithana S R, Jewell D A, Tanhauser S M, LoGrasso P V, Wynns G C, Laipis P J, Silverman D N
Abstract excerpt
Among the isozymes of carbonic anhydrase, isozyme III is the least efficient in the catalysis of the hydration of CO2 and was previously thought to be unaffected by proton transfer from buffers to the active site. We report that buffers of small size, especially imidazole, increase the rate of catalysis by human carbonic anhydrase III (HCA III) of (1) 18O exchange between HCO3- and water measured by...
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