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Single-Dose Protection against<i>Plasmodium berghei</i>by a Simian Adenovirus Vector Using a Human Cytomegalovirus Promoter Containing Intron A

7 Feb 2008

Abstract excerpt

Human adenovirus serotype 5 (AdH5) vector vaccines elicit strong immune responses to the encoded antigen and have been used in various disease models. We designed AdH5 vectors expressing antigen under the control of a human cytomegalovirus (HCMV) immediate-early promoter containing its intron A sequence. The transcriptional levels of antigen and immune responses to antigen for vectors with the HCMV promoter with...

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PMID: 18256155
DOI: 10.1128/jvi.02568-07

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