Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comparative Study of Effects of Vonoprazan and Esomeprazole on Antiplatelet Function of Clopidogrel or Prasugrel in Relation to CYP2C19 Genotype.

Clinical pharmacology and therapeutics - 1 May 2018

Kagami Takuma, Yamade Mihoko, Suzuki Takahiro, Uotani Takahiro, Hamaya Yasushi, Iwaizumi Moriya, Osawa Satoshi, Sugimoto Ken, Umemura Kazuo, Miyajima Hiroaki, Furuta Takahisa

Abstract excerpt

Drug-drug interaction between antiacid and antiplatelet agents has not been fully elucidated. Vonoprazan, a new potassium competitive acid blocker, has been available in Japan. CYP2C19 and CYP3A4 are involved in the metabolism of clopidogrel, prasugrel, esomeprazole, and vonoprazan. Using a P2Y12 assay, we compared the effects of vonoprazan and esomeprazole on the antiplatelet functions of clopidogrel or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Platelets
Share to Clopidogrel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C19

Share to Drug Interactions

Share to Platelet Aggregation

Share to Platelet Aggregation Inhibitors

Share to Prasugrel Hydrochloride

Share to Pyrroles

Source

Identifiers

PMID: 28875498
DOI: 10.1002/cpt.863

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comparative Study of Effects of Vonoprazan and Esomeprazole on Antiplatelet Function of Clopidogrel or Prasugrel in Relation to CYP2C19 Genotype.PMID 28875498Read ↗

Evaluation of the INNOVANCE PFA P2Y assay and its association with CYP2C19 genotypes.Semantic proximity Read ↗

Effects of CYP2C19 allelic variants on inhibition of platelet aggregation and major adverse cardiovascular events in Japanese patients with acute coronary syndrome: The PRASFIT-ACS study.Semantic proximity Read ↗

A Randomized Study of the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of Clopidogrel in Three Different CYP2C19 Genotype Groups of Healthy Japanese Subjects.Semantic proximity Read ↗

A physiologically-based pharmacokinetic model of clopidogrel in populations of European and Japanese ancestry: an evaluation of CYP2C19 activitySemantic proximity Read ↗

Impact of CYP2C19 polymorphisms on the antiplatelet effect of clopidogrel in an actual clinical setting in Japan.Semantic proximity Read ↗

Correlation between the CYP2C19 phenotype status and the results of three different platelet function tests in cardiovascular disease patients receiving antiplatelet therapy: an emphasis on newly introduced platelet function analyzer-200 P2Y test.Semantic proximity Read ↗

New P2Y12 antagonists.Semantic proximity Read ↗

The influence of omeprazole on platelet inhibition of clopidogrel in various CYP2C19 mutant alleles.Semantic proximity Read ↗

Potent acid inhibition by vonoprazan in comparison with esomeprazole, with reference to CYP2C19 genotype.Semantic proximity Read ↗

Ticlopidine with Ginkgo Biloba extract: a feasible combination for patients with acute cerebral ischemia.Semantic proximity Read ↗

Comparison of Modified Impedance Whole Blood Platelet Aggregation Method Detecting Platelet Function in ACS Patients with Different CYP2C19 Genotypes.Semantic proximity Read ↗

Non-antiplatelet effect of clopidogrel: improving endothelial function in Chinese healthy subjects with different CYP2C19 genotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.