Article
Heterozygous deletion at the RLN1 locus in a family with testicular germ cell cancer identified by integrating copy number variation data with phenome and interactome information.
International journal of andrology - 1 Aug 2011
Edsgärd D, Scheel M, Hansen N T, Ralfkiaer U, Jensen T S, Skakkebaek N E, Brunak S, Gupta R, Rajpert-De Meyts E, Ottesen A M
Abstract excerpt
To search for disease-related copy number variations (CNVs) in families with a high frequency of germ cell tumours (GCT), we analysed 16 individuals from four families by array comparative genomic hybridization (aCGH) and applied an integrative systems biology algorithm that prioritizes risk-associated genes among loci targeted by CNVs. The top-ranked candidate, RLN1, encoding a Relaxin-H1 peptide, although only...
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