Article
Downregulation of Filamin A interacting protein 1-like is associated with promoter methylation and induces an invasive phenotype in ovarian cancer.
Molecular cancer research : MCR - 1 Aug 2011
Burton Elizabeth R, Gaffar Aneesa, Lee Soo Jin, Adeshuko Folashade, Whitney Kathleen D, Chung Joon-Yong, Hewitt Stephen M, Huang Gloria S, Goldberg Gary L, Libutti Steven K, Kwon Mijung
Abstract excerpt
Ovarian cancer is the most lethal gynecologic malignancy with a five-year survival rate below 25% for patients with stages III and IV disease. Identifying key mediators of ovarian cancer invasion and metastasis is critical to the development of more effective therapeutic interventions. We previously identified Filamin A interacting protein 1-like (FILIP1L) as an important mediator of cell proliferation and...
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