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Article

The oncoprotein p28GANK establishes a positive feedback loop in β-catenin signaling

21 Jun 2011

Abstract excerpt

p28(GANK) (also known as PSMD10 or gankyrin) is a novel oncoprotein that is highly expressed in hepatocellular carcinoma (HCC). Through its interaction with various proteins, p28(GANK) mediates the degradation of the tumor suppressor proteins Rb and p53. Although p53 was reported to downregulate β-catenin, whether p28(GANK) is involved in the regulation of β-catenin remains uncertain. Here we report that both...

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PMID: 21691299
DOI: 10.1038/cr.2011.103

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