Article
Structure of the oncoprotein gankyrin in complex with S6 ATPase of the 26S proteasome.
Structure (London, England : 1993) - 1 Feb 2007
Nakamura Yoshihiro, Nakano Kazumi, Umehara Takashi, Kimura Mayumi, Hayashizaki Yoshihide, Tanaka Akiko, Horikoshi Masami, Padmanabhan Balasundaram, Yokoyama Shigeyuki
Abstract excerpt
Gankyrin is an oncoprotein commonly overexpressed in most hepatocellular carcinomas. Gankyrin interacts with S6 ATPase of the 19S regulatory particle of the 26S proteasome and enhances the degradation of the tumor suppressors pRb and p53. Here, we report the structure of gankyrin in complex with the C-terminal domain of S6 ATPase. Almost all of the seven ankyrin repeats of gankyrin interact, through its concave...
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