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Article

RNA Binding Protein CUGBP1 Inhibits Liver Cancer in a Phosphorylation-Dependent Manner.

Molecular and cellular biology - 15 Aug 2017

Lewis Kyle, Valanejad Leila, Cast Ashley, Wright Mary, Wei Christina, Iakova Polina, Stock Lauren, Karns Rebekah, Timchenko Lubov, Timchenko Nikolai

Abstract excerpt

Despite intensive investigations, mechanisms of liver cancer are not known. Here, we identified an important step of liver cancer, which is the neutralization of tumor suppressor activities of an RNA binding protein, CUGBP1. The translational activity of CUGBP1 is activated by dephosphorylation at Ser302. We generated CUGBP1-S302A knock-in mice and found that the reduction of translational activity of CUGBP1...

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Identifiers

PMID: 28559429
DOI: 10.1128/MCB.00128-17
PMCID: PMC5533886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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