Article
Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2011
O'Connell Motherway Mary, Zomer Aldert, Leahy Sinead C, Reunanen Justus, Bottacini Francesca, Claesson Marcus J, O'Brien Frances, Flynn Kiera, Casey Patrick G, Munoz Jose Antonio Moreno, Kearney Breda, Houston Aileen M, O'Mahony Caitlin, Higgins Des G, Shanahan Fergus, Palva Airi, de Vos Willem M, Fitzgerald Gerald F, Ventura Marco, O'Toole Paul W, van Sinderen Douwe
Abstract excerpt
Development of the human gut microbiota commences at birth, with bifidobacteria being among the first colonizers of the sterile newborn gastrointestinal tract. To date, the genetic basis of Bifidobacterium colonization and persistence remains poorly understood. Transcriptome analysis of the Bifidobacterium breve UCC2003 2.42-Mb genome in a murine colonization model revealed differential expression of a type IVb...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.