Article
Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2011
Josefsson Lina, King Martin S, Makitalo Barbro, Brännström Johan, Shao Wei, Maldarelli Frank, Kearney Mary F, Hu Wei-Shau, Chen Jianbo, Gaines Hans, Mellors John W, Albert Jan, Coffin John M, Palmer Sarah E
Abstract excerpt
Neither the number of HIV-1 proviruses within individual infected cells in HIV-1-infected patients nor their genetic relatedness within individual infected cells and between cells and plasma virus are well defined. To address these issues we developed a technique to quantify and genetically characterize HIV-1 DNA from single infected cells in vivo. Analysis of peripheral blood CD4(+) T cells from nine patients...
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