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Transgenic expression of full-length 2',5'-oligoadenylate synthetase 1b confers to BALB/c mice resistance against West Nile virus-induced encephalitis.

Virology - 15 Aug 2011

Simon-Chazottes Dominique, Frenkiel Marie-Pascale, Montagutelli Xavier, Guénet Jean-Louis, Desprès Philippe, Panthier Jean-Jacques

Abstract excerpt

Susceptibility of inbred strains to infection with West Nile virus (WNV) has been genetically associated with an arginine-to-a nonsense codon substitution at position 253 (R253X) in the predicted sequence of the murine 2',5'-oligoadenylate synthetase 1B (OAS1B) protein. We introduced by transgenesis the Oas1b cDNA from MBT/Pas mice carrying the R253 codon (Oas1b(MBT)) into BALB/c mice homozygous for the X253...

Topics

2',5'-Oligoadenylate Synthetase
Animals
Gene Expression Regulation, Enzymologic
Genetic Engineering
Genetic Predisposition to Disease
Mice
Mice, Inbred BALB C
Mice, Transgenic
RNA, Messenger
West Nile Fever

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West Nile virus

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PMID: 21683973
DOI: 10.1016/j.virol.2011.05.018

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