Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transgenic expression of full-length 2',5'-oligoadenylate synthetase 1b confers to BALB/c mice resistance against West Nile virus-induced encephalitis.

Virology - 15 Aug 2011

Simon-Chazottes Dominique, Frenkiel Marie-Pascale, Montagutelli Xavier, Guénet Jean-Louis, Desprès Philippe, Panthier Jean-Jacques

Abstract excerpt

Susceptibility of inbred strains to infection with West Nile virus (WNV) has been genetically associated with an arginine-to-a nonsense codon substitution at position 253 (R253X) in the predicted sequence of the murine 2',5'-oligoadenylate synthetase 1B (OAS1B) protein. We introduced by transgenesis the Oas1b cDNA from MBT/Pas mice carrying the R253 codon (Oas1b(MBT)) into BALB/c mice homozygous for the X253...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 2',5'-Oligoadenylate Synthetase
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Engineering

Share to Mice, Inbred BALB C

Share to Mice, Transgenic

Share to RNA, Messenger

Share to West Nile Fever

Share to West Nile virus

Source

Identifiers

PMID: 21683973
DOI: 10.1016/j.virol.2011.05.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transgenic expression of full-length 2',5'-oligoadenylate synthetase 1b confers to BALB/c mice resistance against West Nile virus-induced encephalitis.PMID 21683973Read ↗

Oas1b-dependent Immune Transcriptional Profiles of West Nile Virus Infection in the Collaborative CrossSemantic proximity Read ↗

A nonsense mutation in the gene encoding 2'-5'-oligoadenylate synthetase/L1 isoform is associated with West Nile virus susceptibility in laboratory mice.Semantic proximity Read ↗

Infection of mouse neurones by West Nile virus is modulated by the interferon-inducible 2'-5' oligoadenylate synthetase 1b protein.Semantic proximity Read ↗

Innate resistance to flavivirus infections and the functions of 2'-5' oligoadenylate synthetases.Semantic proximity Read ↗

The chicken 2'-5' oligoadenylate synthetase A inhibits the replication of West Nile VirusSemantic proximity Read ↗

Single nucleotide polymorphisms in genes for 2'-5'-oligoadenylate synthetase and RNase L inpatients hospitalized with West Nile virus infection.Semantic proximity Read ↗

Knock-in of the Oas1b(r) allele into a flavivirus-induced disease susceptible mouse generates the resistant phenotype.Semantic proximity Read ↗

Positional cloning of the murine flavivirus resistance geneSemantic proximity Read ↗

Genetic variation in OAS1 is a risk factor for initial infection with West Nile virus in man.Semantic proximity Read ↗

RNase L Plays a Role in the Antiviral Response to West Nile VirusSemantic proximity Read ↗

Identification of Novel Host Cell Binding Partners of Oas1b, the Protein Conferring Resistance to Flavivirus-Induced Disease in MiceSemantic proximity Read ↗

Transgenic inhibitors of RNA interference in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.