Article
Impact of homoplasy on variable numbers of tandem repeats and spoligotypes in Mycobacterium tuberculosis.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jun 2012
Reyes Josephine F, Chan Carmen H S, Tanaka Mark M
Abstract excerpt
Homoplasy is the occurrence of genotypes that are identical by state but not by descent. It arises through a number of means including convergent and reverse evolution, and horizontal gene transfer. When using molecular markers that are based on sequences possessing a finite number of character states, such as VNTR or spoligotypes, this is an unavoidable phenomenon. Here we discuss the extent of homoplasy and its...
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