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Article

The role of trimerization in the osmoregulated betaine transporter BetP.

EMBO reports - 17 Jun 2011

Perez Camilo, Khafizov Kamil, Forrest Lucy R, Krämer Reinhard, Ziegler Christine

Abstract excerpt

The osmoregulated betaine transporter BetP is a stable trimer. Structural studies have shown that individual protomers can adopt distinct transport conformations, implying a functional role for the trimeric state in transport, although the role of trimerization in regulation is not yet understood. We designed putative monomeric mutants by molecular-dynamics simulations and in silico alanine-scanning mutagenesis....

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Identifiers

PMID: 21681199
DOI: 10.1038/embor.2011.102
PMCID: PMC3147255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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