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Article

Dipeptidyl Peptidases as Survival Factors in Ewing Sarcoma Family of Tumors

17 Jun 2011

Abstract excerpt

Ewing sarcoma family of tumors (ESFT) is a group of aggressive pediatric malignancies driven by the EWS-FLI1 fusion protein, an aberrant transcription factor up-regulating specific target genes, such as neuropeptide Y (NPY) and its Y1 and Y5 receptors (Y5Rs). Previously, we have shown that both exogenous NPY and endogenous NPY stimulate ESFT cell death via its Y1 and Y5Rs. Here, we demonstrate that this effect is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 21680731
DOI: 10.1074/jbc.m111.224089

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