Article
Expression of cellular FLICE inhibitory protein, caspase-8, and protease inhibitor-9 in Ewing sarcoma and implications for susceptibility to cytotoxic pathways.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2007
de Hooge Alfons S K, Berghuis Dagmar, Santos Susy Justo, Mooiman Esther, Romeo Salvatore, Kummer J Alain, Egeler R Maarten, van Tol Maarten J D, Melief Cornelis J M, Hogendoorn Pancras C W, Lankester Arjan C
Abstract excerpt
PURPOSE: Ewing sarcoma is a common pediatric bone tumor with an unfavorable prognosis for metastatic or recurrent disease. Cellular immunotherapy may provide new treatment options and depends on the cytolytic death receptor and perforin/granzyme pathways. Expression of death receptor pathway inhibitor cellular FLICE inhibitory protein (cFLIP), initiator caspase-8, and granzyme B inhibitor protease inhibitor-9...
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