Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protective effects of prepubertal genistein exposure on mammary tumorigenesis are dependent on BRCA1 expression.

Cancer prevention research (Philadelphia, Pa.) - 1 Sept 2011

de Assis Sonia, Warri Anni, Benitez Carlos, Helferich William, Hilakivi-Clarke Leena

Abstract excerpt

This study investigated whether prepubertal dietary exposure to genistein reduces mammary tumorigenesis by upregulating Brca1 expression in mice. Heterozygous Brca1(+/-) mice and their wild-type (WT) littermates were fed control AIN93G diet or 500 ppm genistein-supplemented AIN93G diet from postnatal day (PND) 15 to PND30 and then switched to AIN93G diet. Prepubertal dietary exposure to genistein reduced...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Feed
Share to Estrogen Receptor alpha

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, BRCA1

Share to Genistein

Share to Mammary Glands, Animal

Share to Mammary Neoplasms, Animal

Share to Receptor, ErbB-2

Share to Receptors, Progesterone

Source

Open in PubMed Open full text

Identifiers

PMID: 21680703
DOI: 10.1158/1940-6207.CAPR-10-0346
PMCID: PMC3615976

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protective effects of prepubertal genistein exposure on mammary tumorigenesis are dependent on BRCA1 expression.PMID 21680703Read ↗

The role of early life genistein exposures in modifying breast cancer risk.Semantic proximity Read ↗

In utero exposure of rats to high-fat diets perturbs gene expression profiles and cancer susceptibility of prepubertal mammary glands.Semantic proximity Read ↗

Modulation of immune response following dietary genistein exposure in F0 and F1 generations of C57BL/6 mice: evidence of thymic regulation.Semantic proximity Read ↗

Role of ERalpha in the differential response of Stat5a loss in susceptibility to mammary preneoplasia and DMBA-induced carcinogenesis.Semantic proximity Read ↗

Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer.Semantic proximity Read ↗

In utero exposure to maternal diets containing soy protein isolate, but not genistein alone, protects young adult rat offspring from NMU-induced mammary tumorigenesisSemantic proximity Read ↗

Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene.Semantic proximity Read ↗

Lifelong exposure to n-3 PUFA affects pubertal mammary gland development.Semantic proximity Read ↗

Prepubertal physical activity up-regulates estrogen receptor beta, BRCA1 and p53 mRNA expression in the rat mammary gland.Semantic proximity Read ↗

Combined Broccoli Sprouts and Green Tea Polyphenols Contribute to the Prevention of Estrogen Receptor-Negative Mammary Cancer via Cell Cycle Arrest and Inducing Apoptosis in HER2/neu Mice.Semantic proximity Read ↗

The PPARγ agonist efatutazone increases the spectrum of well-differentiated mammary cancer subtypes initiated by loss of full-length BRCA1 in association with TP53 haploinsufficiency.Semantic proximity Read ↗

Absence of full-length Brca1 sensitizes mice to oxidative stress and carcinogen-induced tumorigenesis in the esophagus and forestomach.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.