Article
The cytoplasmic domain of Marburg virus GP modulates early steps of viral infection.
Journal of virology - 1 Aug 2011
Mittler Eva, Kolesnikova Larissa, Hartlieb Bettina, Davey Robert, Becker Stephan
Abstract excerpt
Marburg virus infection is mediated by the only viral surface protein, GP, a trimeric type I transmembrane protein. While its ectodomain mediates receptor binding and fusion of viral and cellular membranes and its transmembrane domain is essential for the recruitment of GP into budding particles by the matrix protein VP40, the role of the short cytoplasmic domain has remained enigmatic. Here we show that a...
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