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Article

Cyp1b1 Regulates Ocular Fissure Closure Through a Retinoic Acid-Independent Pathway.

Investigative ophthalmology & visual science - 1 Feb 2017

Williams Antionette L, Eason Jessica, Chawla Bahaar, Bohnsack Brenda L

Abstract excerpt

Purpose: Mutations in the CYP1B1 gene are the most commonly identified genetic causes of primary infantile-onset glaucoma. Despite this disease association, the role of CYP1B1 in eye development and its in vivo substrate remain unknown. In the present study, we used zebrafish to elucidate the mechanism by which cyp1b1 regulates eye development. Methods: Zebrafish eye and neural crest development were analyzed...

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Identifiers

PMID: 28192799
DOI: 10.1167/iovs.16-20235
PMCID: PMC5308778

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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