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Article

Selection and analysis of galactose metabolic pathway variants of a mouse liver cell line.

Molecular and cellular biology - 1 Sept 1990

Zaret K S, Stevens K A

Abstract excerpt

To study the genetic expression and regulation of galactose-metabolizing enzymes, we mutagenized the mouse liver H2.35 cell line and selected for cell clones resistant to the toxic galactose analog, 2-deoxy-D-galactose (2-DOG). One cloned line, designated H12.10, was stably resistant to high levels of 2-DOG and was completely deficient in galactokinase activity. Galactokinase activity and growth sensitivity to...

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Identifiers

PMID: 2167434
DOI: 10.1128/mcb.10.9.4582-4589.1990
PMCID: PMC361046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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