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Article

GALT deficiency causes UDP-hexose deficit in human galactosemic cells.

Glycobiology - 1 Apr 2003

Lai K, Langley S D, Khwaja F W, Schmitt E W, Elsas L J

Abstract excerpt

Previously we reported that stable transfection of human UDP-glucose pyrophosphorylase (hUGP2) rescued galactose-1-phosphate uridyltransferase (GALT)-deficient yeast from "galactose toxicity." Here we test in human cell lines the hypothesis that galactose toxicity was caused by excess accumulation of galactose-1-phosphate (Gal-1-P), inhibition of hUGP2, and UDP-hexose deficiency. We found that SV40-transformed...

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Identifiers

PMID: 12626383
DOI: 10.1093/glycob/cwg033

Genes

GALT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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