Article
Comparative effects of chlorpyrifos in wild type and cannabinoid Cb1 receptor knockout mice.
Toxicology and applied pharmacology - 1 Nov 2011
Baireddy Praveena, Liu Jing, Hinsdale Myron, Pope Carey
Abstract excerpt
Endocannabinoids (eCBs) modulate neurotransmission by inhibiting the release of a variety of neurotransmitters. The cannabinoid receptor agonist WIN 55.212-2 (WIN) can modulate organophosphorus (OP) anticholinesterase toxicity in rats, presumably by inhibiting acetylcholine (ACh) release. Some OP anticholinesterases also inhibit eCB-degrading enzymes. We studied the effects of the OP insecticide chlorpyrifos...
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