Article
Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses.
Molecular psychiatry - 1 May 2012
Visscher P M, Goddard M E, Derks E M, Wray N R
Abstract excerpt
In this article, we review some of the data that contribute to our understanding of the genetic architecture of psychiatric disorders. These include results from evolutionary modelling (hence no data), the observed recurrence risk to relatives and data from molecular markers. We briefly discuss the common-disease common-variant hypothesis, the success (or otherwise) of genome-wide association studies, the...
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