Article
Genotype-independent in vivo oxidative stress following a methionine loading test: maximal platelet activation in subjects with early-onset thrombosis.
Thrombosis research - 1 Oct 2011
Di Minno Matteo Nicola Dario, Pezzullo Salvatore, Palmieri Vittorio, Coppola Antonio, D'Angelo Armando, Sampietro Francesca, Cavalca Viviana, Tremoli Elena, Di Minno Giovanni
Abstract excerpt
BACKGROUND: Methionine ingestion (100mg/kg) identifies subjects in whom fasting total homocysteine (tHcy) may be normal but the post-methionine load (PML) tHcy is abnormally high. METHODS: In 96 subjects [54 M/42 F, 40.4 ± 12.3 yrs old; 28 with the 68 bp844 ins of the cystathionine-β-synthase gene (CBSins+); 20 homozygotes for the C677T mutation of the methylene-tetrahydrofolate reductase gene (MTHFR++); 13 with...
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