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Article

Oxidative stress and platelet activation in subjects with moderate hyperhomocysteinaemia due to MTHFR 677 C→T polymorphism.

Thrombosis and haemostasis - 1 Sept 2012

Dragani Alfredo, Falco Angela, Santilli Francesca, Basili Stefania, Rolandi Giancarlo, Cerasa Loredana, Lattanzio Stefano, Ciabattoni Giovanni, Patrono Carlo, Davì Giovanni

Abstract excerpt

The methylenetetrahydrofolate reductase (MTHFR) 677 C→T polymorphism may be associated with elevated total homocysteine (tHcy) levels, an independent risk factor for cardiovascular disease. It was the study objective to evaluate in vivo lipid peroxidation and platelet activation in carriers of the MTHFR 677 C→T polymorphism and in non-carriers, in relation to tHcy and folate levels. A cross-sectional comparison...

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Source

Identifiers

PMID: 22782530
DOI: 10.1160/TH11-12-0899

Genes

MTHFR
PGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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