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Article

Evaluation of spontaneous propulsive movement as a screening tool to detect rescue of Parkinsonism phenotypes in zebrafish models.

Neurobiology of disease - 1 Oct 2011

Farrell Thomas C, Cario Clinton L, Milanese Chiara, Vogt Andreas, Jeong Jong-Hyeon, Burton Edward A

Abstract excerpt

Zebrafish models of human neuropsychiatric diseases offer opportunities to identify novel therapeutic targets and treatments through phenotype-based genetic or chemical modifier screens. In order to develop an assay to detect rescue of zebrafish models of Parkinsonism, we characterized spontaneous zebrafish larval motor behavior from 3 to 9 days post fertilization in a microtiter plate format suitable for...

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PMID: 21669287
DOI: 10.1016/j.nbd.2011.05.016
PMCID: PMC3153634

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